Eric Kasamba
University of Lubumbashi, Democratic Republic of the Congo
Title: Correction tests of intestinal translocation Bactrian by supplementation with yogurt when ARV treatment
Biography
Biography: Eric Kasamba
Abstract
Context Infection with HIV causes, among other misdeeds, deregulation of the immune balance in the digestive tract that promotes bacterial passages or bacterial fragments in the bloodstream. This is one of the causes of chronic inflammation that persists among HIV-positive even under effective antiretroviral therapy. This inflammation followed by assaying sCD14 explains much of co morbidities that appear excessive in people with HIV, even taking into account the traditional risk factors and the fact to be treated. One could try to restore the intestinal flora with probiotics Methodology 150 naïve patients received in 5 clinical Lubumbashi (Congo-DRC) were randomized using a factorial design to receive bi LPV / r tablets compared to NVP combined with TDF / FTC or ZDV / 3TC for 24 weeks. 50 and 25 patients on NVP LPV / r have taken over 250g natural yoghurt per week for 24 weeks, while 50 and 25 patients were evaluated respectively as NVP in LVP / r without any supplementation. Viral load and CD4 and sCD14 assay were made at baseline and after 24 weeks. Results In patients on ARVs without any supplementation, base line the median CD4 and viral load and that of sCD14 are respectively for the NVP : CD4: 116 /μl, VL: 5,2log copies and sCD 14 : 6600ng / ml; S24 after CD4 179 /μl VL and 3.2 log copy sCD 14: 4600ng / ml. And the arm LPV / r: 109 / μl and 5, 0 and log copies sCD 14: 5600ng / ml; S24 after CD4 195 /μl. VL and 2.5 log copies sCD 14: 4300ng / ml. For patients undergoing ARV yoghurt and under the line bases were as follows: Patients receiving NVP D0: CD4121 / μl, VL 5, 3 log 14 copies and sCD: 6040ng / ml and CD4 415 after S24 /μl .VL 1, 7 log copies and sCD 14: 2600ng / ml. And the arm LPV / r: 129 / μl and VL 5, 0 log copies, sCD 14: 6100ng / ml and CD4 S24 after 405 / μl and VL:1.7 log copies sCD 14: 2800ng / ml Conclusion Our results establish that the yogurt inhibits intestinal bacterial translocation and significantly improves the quality of biological parameters in AIDS infection.